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. 2024 Aug 12;8(11):2235–2249. doi: 10.1038/s41562-024-01951-3

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, A bar chart showing the number of significant TWAS genes per transcripts found of four personality traits with significant findings in respective subtissues. Scatter plots of neuroticism (b), agreeableness (c), extraversion (d) and openness (e) with TWAS z-scores of each gene transcript plotted on the y axis and its respective chromosomal location plotted on the x axis. The significant hits are shown in red circles with mapped gene names as labels. The blue horizontal line indicates the significance threshold of the z-score corresponding to the Bonferroni-corrected, two-sided P value. Conscientiousness data is reported in Supplementary Table 22.