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. 2024 Nov 20;9:327. doi: 10.1038/s41392-024-02058-x

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© The Author(s) 2024, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Study overview. As recently published in Cell, Mucker et al. conducted an mpox vaccine study in non-human primates (NHP), comparing a novel mRNA vaccine (mRNA-1769) to a live-attenuated Modified Vaccinia virus Ankara (MVA) vaccine. Following vaccination, NHPs were challenged with the mpox virus. While vaccination with mRNA-1769 and MVA resulted in similar protection against lethality, mRNA-1769 vaccination led to a stronger reduction of mpox lesions and viremia and induced superior antibody titers and functionality. A multivariate correlates analysis revealed that neutralizing and Fc-mediated antibody functions were associated with vaccine-induced protection. Created in BioRender