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Characterisation of the binding kinetics of P2c2s and P34 with the extracellular domain of PD1 (residues 21-168;C-terminal His-tag).
| Aptamer | Dissociation constant | Association rate constant | Dissociation rate constant |
|---|---|---|---|
| P2c2s | Kd = 934 nM | kon = 603,4 M −1s −1 | koff = 0,00455 s −1, |
| P34 | Kd = 508 nM | kon = 3842,33 M−1 s−1 | koff = 0,001939 s−1 |
