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. 2024 Nov 19;9:228. doi: 10.1038/s41541-024-01011-x

Fig. 6. Post-vaccination NAI titers are a correlate of protection in the ferret model.

Fig. 6

A Ferrets with severe symptoms showed significantly lower NAI titers than those classified as non-severe. B NAI titers can correctly predict disease severity in ferrets since the area under the curve (AUC) of the receiver operating characteristics (ROC) curve for NAI titers was significantly higher than an uninformative biomarker. C Log2 NAI titer of 8.9 (NAI titer of 477) was the optimum NAI titer cutoff at D42 that best distinguishes severe from non-severe cases as determined by the Youden index.