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. 2024 Nov 19;9:228. doi: 10.1038/s41541-024-01011-x

Fig. 7. rTET-NA retains its immunogenicity following octavalent HA and NA vaccination in ferrets.

Fig. 7

Naïve ferrets were vaccinated twice (21 days apart; (A)) with quadrivalent rTET-NA plus quadrivalent baculovirus-HA (B) from strains included in the quadrivalent 2018–19 Northern hemisphere seasonal influenza vaccine. NAI titers against vaccinal N2, N1, B/Victoria/2/87-like and B/Yamagata/16/88-like strains were determined in sera from vaccinated ferrets three weeks after each immunization (C). *p < 0.05; **p < 0.01; ***p < 0.001 (the red text/symbols are comparisons between 4xHA and 4x NA or 4xHA + 4xNA at matched dose and time). For all comparisons between 1 dose and 2 doses, all groups that received NA-containing formulations had significantly higher NAI titers after 2 doses (p < 0.001), but there were no significant differences for groups that received formulations containing only HA (4xHA). The solid lines represent the average measurement, and the dashed lines indicate the lower limit of detection (LLOD).