Table 3. Prediction Probability and Coverage of the Rat and Human P450 Models.

P450	distance from the predicted probability of 0.5
	0		±0.05		±0.1		±0.15		±0.2
	ROC-AUC	coverage	ROC-AUC	coverage	ROC-AUC	coverage	ROC-AUC	coverage	ROC-AUC	coverage
Rat
CYP1A1	0.84	100%	0.84	97%	0.85	93%	0.84	78%	0.84	73%
CYP1A2	0.80	100%	0.82	92%	0.85	78%	0.88	62%	0.86	42%
CYP2B1	0.73	100%	0.74	88%	0.74	73%	0.80	53%	0.83	47%
CYP2C6	0.93	100%	0.93	97%	0.93	95%	0.93	88%	0.93	87%
CYP2D1	0.81	100%	0.79	97%	0.80	95%	0.82	93%	0.84	90%
CYP2E1	0.69	100%	0.76	80%	0.80	70%	NAa	NA	NA	NA
CYP3A2	0.78	100%	0.78	88%	0.79	75%	0.80	67%	0.80	62%
Human
CYP1A1	0.82	100%	0.82	95%	0.82	93%	0.82	92%	0.82	90%
CYP1A2	0.75	100%	0.77	98%	0.76	97%	0.76	90%	0.76	82%
CYP1B1	0.90	100%	0.90	98%	0.90	98%	0.90	95%	0.90	95%
CYP2A6	0.72	100%	0.69	93%	0.64	87%	0.65	80%	0.67	73%
CYP2B6	0.75	100%	0.75	100%	0.75	98%	0.77	90%	0.78	85%
CYP2C8	0.78	100%	0.78	100%	0.76	97%	0.75	90%	0.75	88%
CYP2C9	0.78	100%	0.79	90%	0.80	78%	0.81	73%	0.82	67%
CYP2C19	0.76	100%	0.78	97%	0.78	97%	0.77	93%	0.76	92%
CYP2D6	0.75	100%	0.75	100%	0.78	97%	0.76	95%	0.76	83%
CYP2E1	0.58	100%	0.63	88%	0.65	73%	0.67	72%	0.78	57%
CYP3A4	0.82	100%	0.84	95%	0.84	92%	0.85	88%	0.88	77%

^aNA; not available.