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. 2024 Nov 15;17:8861–8879. doi: 10.2147/JIR.S486412

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© 2024 Yang et al.

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STAT3 silencing reverses the inhibitory effect of CAR on ferroptosis in cardiomyocytes. (A) The expression level of STAT3 was analyzed using Western blotting. *P < 0.05 vs sh-NC group. (B) The expression of SLC7A11 was evaluated by Western blotting. (C) The lipid ROS level was assessed by flow cytometry. (D) The left panel shows representative images of mitochondrial iron staining (MitoFerro Green) and mitochondrial ROS (MitoSox Red). The right panel indicates the immunofluorescence intensity of iron and ROS. (E) Quantification of GSH, MDA, and SOD in primary cardiomyocytes and HL-1 cells. (F and G) The ratio of cell death was assessed through flow cytometry. n = 3 per group. *P < 0.05 vs Control group, ^#P < 0.05 vs H/R-AGEs group, ^$P < 0.05 vs H/R-AGEs+CAR+sh-NC group.