Fig. 1.

Schematic illustration of effect of PA28γ knockdown in osteoarthritis development (figure was created with BioRender.com). BAX, Bcl-2 Associated X-protein; COL2, type II collagen; COX2, cyclooxygenase-2; GRP78, Glucose-Regulated Protein 78; IL-1, interleukin-1β; iNOS, inducible nitric oxide synthase; IRE1α, inositol-requiring enzyme type 1 alpha; MMP, matrix metalloproteinase; PA28γ, proteasome activator 28γ; PERK, protein kinase-like endoplasmic reticulum kinase; SOX9, SRY-Box Transcription Factor 9; STAT3, signal transducer and activator of transcription 3; TBHP, tert-butylhydrogen peroxide.