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. 2024 Nov 20;13(11):659–672. doi: 10.1302/2046-3758.1311.BJR-2023-0361.R2

Fig. 8.

Fig. 8

Knockdown of PA28γ alleviates osteoarthritis (OA) after destabilized medial meniscus (DMM) surgery. a) and i) Aggrecan immunohistochemical staining images and quantitative data of knee joint tissue obtained from Ad-shControl and Ad-shPA28γ mice eight weeks after DMM surgery, measuring scale = 100 μm (n = 3, **p < 0.01, ****p < 0.0001). b) and j) Type II collagen (COL2) immunohistochemical staining images and quantitative data of knee joint tissue obtained from Ad shControl and Ad-shPA28γ mice eight weeks after DMM surgery, measuring scale = 100 μm (n = 3, **p < 0.01, ****p < 0.0001). c) and k) SOX9 immunohistochemical staining images and quantitative data of knee joint tissue obtained from Ad-shControl and Ad-shPA28γ mice eight weeks after DMM surgery, measuring scale = 100 μm (n = 3, **p < 0.01, ***p < 0.001, ****p < 0.0001). d) and l) Matrix metalloproteinase 3 (MMP3) immunohistochemical staining images and quantitative data of knee joint tissue obtained from Ad-shControl and Ad-shPA28γ mice eight weeks after DMM surgery, measuring scale = 100 μm (n = 3, *p < 0.05, **p < 0.01, ****p < 0.0001). e) and m) MMP13 immunohistochemical staining images and quantitative data of knee joint tissue obtained from Ad-shControl and Ad-shPA28γ mice eight weeks after DMM surgery, measuring scale = 100 μm (n = 3, **p < 0.01, ***p < 0.001). f) and n) Interleukin-1β (IL-1β) immunohistochemical staining images and quantitative data of knee joint tissue obtained from Ad-shControl and Ad-shPA28γ mice eight weeks after DMM surgery, measuring scale = 100 μm (n = 3, **p < 0.01, ***p < 0.001, ****p < 0.0001). g) and o) COX2 immunohistochemical staining images and quantitative data of knee joint tissue obtained from Ad-shControl and Ad-shPA28γ mice eight weeks after DMM surgery, measuring scale = 100 μm (n = 3, ****p < 0.0001). h) and p) CHOP immunohistochemical staining images and quantitative data of knee joint tissue obtained from Ad-shControl and Ad-shPA28γ mice eight weeks after DMM surgery, measuring scale = 100 μm (n = 3, **p < 0.01, ****p < 0.0001). ns, not specified.