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Directed evolution of phages resulted in rapid host-range expansion of the phage cocktail. Eight strains were individually challenged with a cocktail of three input phages for the Appelmans protocol for nine rounds. Clinical isolates strains CI00780, CI00795, and CI01788 were removed from the experiment after round 3 due to slow growth rates, designated by the dashed line. Lysis of non-permissive hosts PAK and PA14 was observed by round 4.
