Fig. 1.

PN and PND inhibited the proliferation of HNSCC cell. A 2D structures of PN and PND. B-C Cal27 and Tu686 cells were treated with various concentrations of Dox + L, PN + L, PND + L, CDDP for 48 h, and then cell viability was assessed using the CCK-8 assay. D-G HOK cells were treated with various concentrations of Dox + L, PN + L, PND + L, CDDP for 24 h and 48 h, and then cell viability were assessed using the CCK-8 assay. H-I Cal27 and Tu686 cells were divided into eight groups and treated for 24 h, 48 h, and 72 h, and then OD values was assessed using the CCK-8 assay. J-L The colony formation assay was was used to detect the colony formation of Cal27 and Tu686 cells in different treatment groups. Colony numbers were quantified. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Compared to PBS + L group: #p < 0.001. Compared to PN + L group: +p < 0.001, ¯p > 0.05. All data are shown as the mean ± SD from three independent experiments