Table 4.

Subgroup analysis in patients who underwent fixation (N = 266)

	LR [-] (N = 246)	LR [+] (N = 20)	Univariate P-value	Multivariate P-value
RCC	33 (13.4%)	8 (40.0%)	0.002	0.019
HTN	76 (30.9%)	7 (35.0%)	0.703	NE
DM	49 (19.9%)	6 (30.0%)	0.284	NE
Liver disease	37 (15.0%)	7 (35.0%)	0.021	0.188
Smoking	40 (16.3%)	9 (45.0%)	0.001	0.026
Surgical method (decompression/corpectomy)	168/78	9/11	0.034	0.081
Pathologic fracture	96 (39.0%)	18 (90.0%)	< 0.001	0.034
Number of spinal metastases (1/2/3 or more)	80/146/20	2/2/16	< 0.001	0.001
Number of extraspinal bone metastases (0/1/2/3 or more)	40/114/77/15	1/1/1/17	< 0.001	0.003
Preoperative RTx	142 (57.7%)	8 (40.0%)	0.124	NE
Postoperative RTx	170 (69.1%)	8 (40.0%)	0.008	0.130
SINS	7.69 ± 1.95	10.55 ± 2.16	< 0.001	0.230

Data are expressed as the mean value and standard deviation for continuous variables and numbers for categorical variables

LR, local recurrence; N, number; RCC, renal cell carcinoma; HTN, hypertension; DM, diabetes mellitus; RTx, Radiation therapy; SINS: spinal instability neoplastic score