Table 2.
Clinicopathological variables associated with type III-IV recurrence in the development cohort
| Clinicopathological factors | Odds ratio |
Univariate Analysis | Multivariate Analysis | |||
|---|---|---|---|---|---|---|
| 95% CI | P | Odds ratio |
95% CI | P | ||
| Age(years) | ||||||
| ≤ 45 VS>45 | 3.985 | 2.282–6.985 | 0.000 | 3.758 | 1.786–7.907 | 0.000 |
| Gender | ||||||
| Female VS Male | 2.032 | 0.891–4.636 | 0.092 | - | - | - |
| HBsAg | ||||||
| Positive VS Negative | 1.096 | 0.460–2.613 | 0.836 | - | - | - |
| HBV-DNA | ||||||
| <500 VS ≥ 500 | 1.614 | 0.940–2.772 | 0.083 | - | - | - |
| Tumor size(cm) | ||||||
| <10 VS ≥ 10 | 3.540 | 2.047–6.120 | 0.000 | 3.277 | 1.589–6.759 | 0.001 |
|
Postoperative complications (Clavien-Dindo: grade II ~ IV) |
||||||
| Yes VS No | 6.706 | 2.343–19.198 | 0.000 | 6.249 | 1.723–22.661 | 0.005 |
| Node number | ||||||
| 1 VS 2 VS ≥ 3 | 2.132 | 1.547–2.941 | 0.000 | 2.334 | 1.526–3.572 | 0.000 |
| Edmondson grade | ||||||
| Low VS High/medium | 1.712 | 1.018–2.880 | 0.043 | 1.011 | 0.502–2.038 | 0.975 |
| Tumor capsule | ||||||
| Incomplete VS Complete | 4.507 | 2.617–7.762 | 0.000 | 3.556 | 1.727–7.322 | 0.001 |
| Resection margin(cm) | ||||||
| <1 VS ≥ 1 | 1.231 | 0.706–2.146 | 0.464 | - | - | - |
| MVI | ||||||
| Positive VS Negative | 39.765 | 5.107-309.598 | 0.000 | 5.315 | 0.516–54.732 | 0.160 |
| AFP (ng/ml) | ||||||
| ≤ 400 VS > 400 | 2.296 | 1.343–3.927 | 0.002 | 1.552 | 0.754–3.197 | 0.233 |
| Liver fibrosis (Fib-4 score) | ||||||
| > 3.25 VS ≤ 3.25 | 1.144 | 0.634–2.063 | 0.655 | - | - | - |
| Tumor thrombus types | ||||||
| HVTT VS BDTT VS PVTT | 1.992 | 1.397–2.841 | 0.000 | 1.171 | 0.708–1.938 | 0.538 |
| Postoperative TACE | ||||||
| Yes VS No | 2.469 | 1.460–4.176 | 0.001 | 1.869 | 0.926–3.774 | 0.081 |
| Ki67 | ||||||
| < 30 VS 30 ~ 60 VS > 60 | 3.596 | 2.398–5.393 | 0.000 | 2.761 | 1.654–4.611 | 0.000 |
Notes: HBsAg: Hepatitis B surface antigen; HBV-DNA: Hepatitis B virus deoxyribonucleic acid; AFP: Alpha-fetoprotein; MVI: Microvascular invasion; HVTT: Hepatic vein tumor thrombus; BDTT: Bile duct tumor thrombus; PVTT: Portal vein tumor thrombus