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. 2024 Nov 19;12:35. doi: 10.1186/s40170-024-00364-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 2 — Interaction between mitochondria and other pathway-related proteins. Mitochondria-related protein expression levels are correlated. a Correlation coefficient between each protein. The correlation values (r) are calculated using the Spearman method using GraphPad Prism version 9. b COX1 expression correlates with COX2 expression (r = 0.93). c COX1 expression correlates with DRP1 expression (r = 0.56). d COX2 expression correlates with DRP1 expression (r = 0.46). Mitochondria-related protein expression levels are inversely correlated with glycolytic protein expression levels. e COX1 expression tends to be inversely correlated with that of HK2 (r = -0.52). Mitochondria-related protein expression is not correlated with that of one-carbon metabolism proteins. f COX1 expression is not correlated with that of SHMT2 (r = -0.24). Mitochondria-related protein expression is correlated with that of glutaminolysis-related proteins. g COX1 expression is correlated with GLS1 (r = 0.76). h COX1 expression is correlated with GLDH (r = 0.65)