Fig. 3.

Protein expression of the metabolic pathway of tumor tissues (used as a validation set). Expression of mitochondria-related proteins is correlated with each other and with that of glutaminolysis proteins. a Proteins associated with metabolic pathways in tumor tissues include COX1, COX2, DRP1, HK2, SHMT2, GLS1, GLDH, and actin. b Correlation coefficient between each protein. The correlation values (r) are calculated using the Spearman method using GraphPad Prism version 9. c COX1 expression correlates with COX2 expression (r = 0.88). d COX1 expression correlates with DRP1 expression (r = 0.89). e COX1 expression correlates with GLS1 (r = 0.72). f COX1 expression tends to correlate with GLDH (r = 0.71)