TABLE 1.
Association analysis of autophagy‐related SNPs in the discovery cohorts.
| SNP | Gene | Chr | A1 | MAF | PanScan + PanC4 (n = 15.776) | FinnGen R10 (n = 314.924) | Meta‐analysis (n = 330.700) a | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | Direction | p Het | |||||
| rs9604789 | BID | 22 | A | 0.017 | 1.33 (1.13–1.56) | 4.76E‐04 | 1.34 (1.07–1.68) | .0107 | 1.33 (1.17–1.52) | 1.52E‐05 | ++ | .9375 |
| rs11653998 | ERBB2 | 17 | C | 0.335 | 1.09 (1.04–1.14) | 7.34E‐04 | 1.08 (0.98–1.18) | .1196 | 1.09 (1.04–1.13) | 2.02E‐04 | ++ | .9283 |
| rs11540923 | MAP1LC3B | 16 | C | 0.029 | 0.73 (0.62–0.86) | 1.30E‐04 | 0.52 (0.23–1.16) | .1087 | 0.72 (0.61–0.84) | 4.72E‐05 | − | .4182 |
| rs72552382 | MTOR | 1 | C | 0.015 | 1.52 (1.23–1.88) | 1.33E‐04 | 0.67 (0.22–2.09) | .4911 | 1.48 (1.2–1.82) | 2.89E‐04 | +− | .1659 |
| rs75447274 | NBR1 | 17 | T | 0.031 | 0.77 (0.67–0.90) | 6.50E‐04 | 0.91 (0.67–1.24) | .5697 | 0.80 (0.70–0.91) | 8.94E‐04 | − | .3368 |
| rs78344309 | PEX14 | 1 | T | 0.070 | 0.81 (0.72–0.92) | 9.99E‐04 | 0.87 (0.69–1.10) | .2530 | 0.83 (0.74–0.92) | 5.67E‐04 | − | .6135 |
| rs1515496 | TP63 | 3 | G | 0.389 | 0.88 (0.84–0.92) | 3.50E‐08 | 1.05 (0.94–1.17) | .3907 | 0.89 (0.85–0.93) | 6.27E‐08 | ++ | .1725 |
| rs35389543 | TP63 | 3 | C | 0.099 | 1.17 (1.08–.26) | 1.48E‐04 | 1.15 (0.99–1.34) | .0727 | 1.16 (1.08–1.25) | 2.74E‐05 | − | .8619 |
| rs9882798 | TP63 | 3 | A | 0.096 | 1.17 (1.08–1.26) | 1.39E‐04 | 1.05 (0.90–1.22) | .5464 | 1.14 (1.06–1.22) | 2.61E‐04 | ++ | .2141 |
Note: The TP63 rs1515496 SNPs (or other SNPs in strong LD) is a well‐established susceptibility markers for PDAC. p < .05 in bold.
Abbreviations: A1, effect‐allele; SNP, single nucleotide polymorphism.
a
Meta‐analysis: PanScan + PanC4 + FinnGen; FinnGen releases DF10 according to a random effect model.