Table 2. Number of uORFs in GRCh38 that were conserved in each of four other human genomes, at varying levels of conservation.
Level 7 indicates a perfect match contained in the 5’ UTR region of a protein-coding transcript at the correct gene locus. Values in parentheses are the number of cases in which the best sequence match occurred at a different genomic location (>1kbp away), not the one previously annotated.
Conservation score | Han1 | CHM13 | Ash1 | PR1 | |
---|---|---|---|---|---|
Conserved | 7 | 1,931 | 1,943 | 2,078 | 2,065 |
6 | 14 | 15 | 1 | 2 | |
5 | 66 | 68 | 6 | 4 | |
4 | 25 (5) | 27 (5) | 5 (0) | 2 (0) | |
Subtotal | 2,036 (5) | 2,053 (5) | 2,090 | 2,073 | |
Not conserved | 3 | 146 | 131 | 108 | 125 |
2 | 2 | 1 | 0 | 0 | |
1 | 4 | 5 | 0 | 0 | |
0 | 6 | 4 | 1 | 1 | |
Subtotal | 158 | 141 | 109 | 126 |