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. 2024 Nov 20;20(11):e1012543. doi: 10.1371/journal.pcbi.1012543

Table 2. Number of uORFs in GRCh38 that were conserved in each of four other human genomes, at varying levels of conservation.

Level 7 indicates a perfect match contained in the 5’ UTR region of a protein-coding transcript at the correct gene locus. Values in parentheses are the number of cases in which the best sequence match occurred at a different genomic location (>1kbp away), not the one previously annotated.

Conservation score Han1 CHM13 Ash1 PR1
Conserved 7 1,931 1,943 2,078 2,065
6 14 15 1 2
5 66 68 6 4
4 25 (5) 27 (5) 5 (0) 2 (0)
Subtotal 2,036 (5) 2,053 (5) 2,090 2,073
Not conserved 3 146 131 108 125
2 2 1 0 0
1 4 5 0 0
0 6 4 1 1
Subtotal 158 141 109 126