Fig. 5.

Gene clusters from Lachnospiraceae exhibit the most stable and abundant capacity for UA consumption. Panel 1: Gene clusters from the Lachnospiraceae family demonstrate a significant and consistent capacity for UA consumption. The asterisk on the left highlights SGBs belonging to the Lachnospiraceae family. The red font emphasizes the six indicator species outlined in Fig. 4. The squares represent the prevalence of UA gene clusters across individuals at sequential time points, with frequencies above ten highlighted in the same color. Panel 2: Spearman's correlation coefficients detail the relationships between the relative abundance of SGBs, where the gene clusters are sourced, and ten fecal metabolites linked to purine metabolism. Correlations with absolute values exceeding 0.2 are indicated in the same color. Statistical significance is denoted as follows: *P < 0.05, **P < 0.01, and ***P < 0.001.