Table 1. Summary of the applied drug treatments and their phenotypic consequences.

Treatment				Liquid culture experiments				Agar plate experiments
Category	Long name	Abbreviation	Mechanism of action	Subinhinitory concentration	CFU compared to control	Cell length [μm]	Cell width [μm]	Subinhinitory concentration	CFU compared to control
First line antibiotics	Isoniazid	INH	Cell wall synthesis inhibitor	150 μg/ml	80%	1.8±0.5	0.41±0.07	2 μg/ml	2.2 %
	Ethambutol	EMB		100 μg/ml	70%	2.0±0.8	0.55±0.17	0.2 μg/ml	10.5 %
	Rifampicin	RIF	RNA synthesis inhibitor	3 μg/ml	60%	6.6±2.4	0.68±0.09	25 μg/ml	0.00052 %
	Combination treatment	COMBO	WHO first line therapy	10 μg/ml PZA, 15 μg/mL INH, 10 μg/ml EMB, 0.3 μg/mL RIF	6%	2.8±0.7	0.47±005	1 μg/ml PZA, 0.2 μg/mL INH, 0.02 μg/ml EMB, 2.5 μg/mL RIF	0.39 %
Second line antibiotics	Ciprofloxacin	CIP	Gyrase inhibitor	0.3 μg/ml	20%	11.1±4.0	0.59±0.1	0.3 μg/ml	0.00018 %
DNA damage controls	Mitomycin-C	MMC	DNA alkylation	0.01 μg/ml	20%	9.8±4.6	0.68±0.11	0.0005 μg/ml	0.96 %
	Ultraviolet radiation	UV	Pyr dimers, DSBs	ND	ND	ND	ND	150 J/m2	11 %
N/A	Non-treated	Mock	N/A	N/A	100%	2.8±0.9	0.44±0.08	N/A	100 %