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. 2024 Sep 30;1(3):umae023. doi: 10.1093/radadv/umae023

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© The Author(s) 2024. Published by Oxford University Press on behalf of the Radiological Society of North America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — (A) Tissue sodium concentration (TSC) and (B) apparent diffusion coefficient (ADC) measurements in noncancerous (normal) tissue and cancerous lesions in the peripheral zone (PZ) and transition zone (TZ) of 6 healthy controls and 20 participants with prostate cancer. Across the participants, a total of 31 tumor lesions were detected (21 PZ, 10 TZ) by multiparametric MRI. Percent differences in (C) TSC (ΔTSC) and (D) ADC (ΔADC) in prostate cancer participants were significantly less than 0% (P < .05), indicating a lower TSC and ADC in PZ and TZ lesions relative to surrounding noncancerous tissue on an individual basis.