Table 4. Safety comparison.

PRP: platelet-rich plasma, PRP-HA: platelet-rich plasma/hyaluronic acid

Study	Sample size	Adverse events
Villanova-López et al. [11]	74	No adverse effects reported (0 patients)
Di Sante et al. [12]	43	No complications reported (0 patients)
Dallari et al. [13]	111	No serious adverse events reported
Nouri et al. [14]	105	Minor side effects (pain, warmth, stiffness) in 17 patients; more pain in the PRP and PRP-HA groups (P-value 0.001)
Doria et al. [15]	80	No major adverse events; significantly higher post-injection pain reaction in the PRP group (P-value 0.043)