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. 2024 Nov 7;15:1469118. doi: 10.3389/fimmu.2024.1469118

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Copyright © 2024 Zhu, Wang, Gu, Zhou, Wu, Xu, Yang, Cai, Shen, Lu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TB infection decreased IL-2 production in IFNγ⁺CD3⁺ T cells. (A, B) Representative flow cytometry histograms (left) and dot graphs (right) illustrated the frequencies of IFNγ⁺CD3⁺ cells (A) and IL-2 producing cells (B) from HC donors and TB patients with Mtb antigen stimulation, respectively (N=6,7). (C) The frequencies of IL-2 producing cells in IFNγ⁺CD3⁺ and IFNγ^-CD3⁺ cells from HC donors and TB patients were determined by flow cytometry after Mtb antigen stimulation, respectively (N=6,7). Results are expressed as mean ± SD. *p < 0.05, ***p < 0.001, ****p < 0.0001. Statistical significance was determined using Student’s t-test (A, B), one-way ANOVA (C). Data represent 3 independent experiments.