Figure 5.

Independent prognostic analysis of risk scores and clinical parameters. (A, B) Forest plot of univariable and multivariate Cox model for survival in NB. “Age_at_diagnosis”: age at diagnosis; “MYCN_status”: the status of the MYCN gene in the tumour cells of a patient with neuroblastoma, a proto-oncogene associated with tumour growth and spread that is amplified in some neuroblastomas and is associated with aggressiveness and poor prognosis of the disease. “PROGRESSION”: in medicine and biology, the development or worsening of a disease or condition. “INSS_stage”: the abbreviation for international neuroblastoma staging system (INSS). INSS stages are as follows (St: Stage), Stage 1: The tumour is confined to the primary site, can be completely resected, and the patient is 18 months of age or older or the tumour diameter is less than or equal to 5 cm; Stage 2A: The tumour is partially resected and the ipsilateral residual tumour does not cross the midline; Stage 2B: partial resection of the tumour with ipsilateral residual tumour crossing the midline; Stage 3: Incomplete resection of the tumour due to invasion of major vascular structures or tumour crossing the midline with residual tumour; Stage 4: Tumour has distant metastases to other parts of the body; Stage 4S: Low risk of metastasis under certain conditions, usually seen in infants. (C) A nomogram to predict 1-year, 2-years, and 3-years survival rates in NB patients. (D) Nomogram-Predicted Probability of 1-3 year OS. (E1–3) Survival-dependent receiver operating characteristic curves for risk score, nomogram, and clinical pathological characteristics.