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. 2024 Jul 8;51(6):809–824. doi: 10.1007/s10928-024-09934-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Simulations of 70 kg healthy individuals (n = 1000) (A) ACTH concentration-time profile and (B) subsequent cortisol production rate (y-axis break). (C) Total cortisol concentration-time profile and (D) subsequent suppression of ACTH pulsatile secretion. Solid lines: Typical profiles. Shaded areas: 90% confidence interval. ACTH: Adrenocorticotropic hormone, EC₅₀: ACTH concentration yielding half-maximum cortisol production, E_max: Maximum cortisol production rate constant, IC₅₀: Unbound cortisol concentration yielding half-maximum ACTH suppression