Fig. 3.

Simvastatin combined with 5-FU is synergistic. A-B The sensitivity to 5-FU and simvastatin in three PC cell lines. C-E After exogenous GGPP (10 μM) supplementation, the sensitivity to 5-FU in three PC cell lines. F-N The synergistic effect of 5-FU and simvastatin was evaluated by collaborative analysis model, and the synergistic concentration was measured respectively. O Cell viability analysis of PANC-1, Panc 02, and MIA PaCa-2 cells after treatment with different conditions for 72 h. Results are presented as mean ± standard deviation. Student’s t test. *P < 0.05, **P < 0.01, ***P < 0.001