Fig. 9.

Correlation between TME, immunotherapy, and PRLPS. A–E The RS had significant positive correlations with infiltrating levels of memory resting CD4 T cells, eosinophils, M2 macrophages, and resting dendritic cells and had significant adverse connections with infiltrating levels of plasma cells. F The OS of patients with high stromal scores was significantly worse compared to those with low stromal scores. G–I The higher the content of resting mast cells and CD8 T cells, the higher the OS. The patients with high neutrophil counts had a worse prognosis than those with low neutrophil counts. J The expression of ICGs between the normal and the tumor groups. K The ICGs expression between the HRG and the poor-risk groups.* p < 0.05, ** p < 0.01, and *** p < 0.001. L, M The relative probabilities to respond to PD1( −)/CTLA4( +) and PD1( −)/CTLA4( −) treatment between the HRG and poor-risk group