Table 1.
Patient demographics and clinical characteristics.
| Characteristics, n (%) | No Brain metastasis (N = 2816) | Brain metastasis (N = 1900) | P Value |
|---|---|---|---|
| Age (years), median (range) | 67(17–85) | 67(37–85) | < 0.001 |
| Age | < 0.001 | ||
| < 65 | 993 (35.3%) | 877 (46.2%) | |
| ≥ 65 | 1823 (64.7%) | 1023 (53.8%) | |
| Sex | 0.545 | ||
| Male | 1555 (55.2%) | 1067 (56.2%) | |
| Female | 1261 (44.8%) | 833 (43.8%) | |
| Race | < 0.001 | ||
| White | 2486 (88.3%) | 1539 (81.0%) | |
| Black | 234 (8.3%) | 246 (12.9%) | |
| Asian or Pacific Islander | 87 (3.1%) | 102 (5.4%) | |
| American Indian/Alaska Native | 9 (0.3%) | 13 (0.7%) | |
| Primary.Site | 0.764 | ||
| Main bronchus | 241 (8.6%) | 149 (7.8%) | |
| Upper lobe, lung | 1432 (50.9%) | 1007 (53.0%) | |
| Middle lobe, lung | 116 (4.1%) | 79 (4.2%) | |
| Lower lobe, lung | 675 (24.0%) | 434 (22.8%) | |
| Overlapping lesion of lung | 42 (1.5%) | 30 (1.6%) | |
| Lung, NOS | 310 (11.0%) | 201 (10.6%) | |
| Surgery | 0.872 | ||
| No | 178 (6.3%) | 114 (6.0%) | |
| Yes | 2631 (93.4%) | 1782 (93.8%) | |
| Others | 7 (0.2%) | 4 (0.2%) | |
| Radiation | < 0.001 | ||
| No | 1808 (64.2%) | 447 (23.5%) | |
| Yes | 990 (35.2%) | 1439 (75.7%) | |
| Others | 18 (0.6%) | 14 (0.7%) | |
| Chemotherapy | 0.005 | ||
| No | 1051 (37.3%)) | 787 (41.4%) | |
| Yes | 1765 (62.7%) | 1113 (58.6%) | |
| Marital.status | < 0.001 | ||
| Married | 1465 (52.0%) | 988 (52.0%) | |
| Single and Unmarried | 370 (13.1%) | 326 (17.2%) | |
| Others | 981 (34.8%) | 586 (30.8%) | |
| Mets.at.DX.bone | < 0.001 | ||
| No | 951 (33.8%) | 1418 (74.6%) | |
| Yes | 1865 (66.2%) | 482 (25.4%) | |
| Mets.at.DX.liver | < 0.001 | ||
| No | 1140 (40.5%) | 1453 (76.5%) | |
| Yes | 1676 (59.5%) | 447 (23.5%) | |
| Mets.at.DX.lung | 0.123 | ||
| No | 2147 (76.2%) | 1486 (78.2%) | |
| Yes | 669 (23.8%) | 414 (21.8%) | |
| Laterality | 0.461 | ||
| Left | 1181 (41.9%) | 793 (41.7%) | |
| Right | 1576 (56.0%) | 1062 (55.9%) | |
| Paired site | 18 (0.6%) | 20 (1.1%) | |
| Others | 41 (1.5%) | 25 (1.3%) | |
| T.stage | < 0.001 | ||
| T1 | 220 (7.8%) | 165 (8.7%) | |
| T2 | 811 (28.8%) | 666 (35.1%) | |
| T3 | 150 (5.3%) | 107 (5.6%) | |
| T4 | 1635 (58.1%) | 962 (50.6%) | |
| N.stage | < 0.001 | ||
| N0 | 405 (14.4%) | 370 (19.5%) | |
| N1 | 265 (9.4%) | 212 (11.2%) | |
| N2 | 1531 (54.4%) | 951 (50.1%) | |
| N3 | 615 (21.8%) | 367 (19.3%) | |
| Tumor.Size | < 0.001 | ||
| Median(IQR) | 50(33–71) | 58(35–73) | |