Figure 2. Presence of possible biases related to time point misalignment (n=200). Possible biases for each report of non-randomised studies are summarised for bias related to: inclusion of prevalent users, post-treatment eligibility criteria, immortal time periods, and classification of treatment arms. Each spoke represents one report. The bricks are a visual representation of the possible bias related to time point misalignment: possible bias, could not assess, or no bias. Every concentric circle represents one of the biases, with bias related to inclusion of prevalent users being the furthest circle from the centre, and bias in classification of treatment arms is the central circle. The most external circle represents an overview of the possible biases for each report (at least one possible bias exists, could not assess, and when no bias exists). The histogram summarises the possible biases for the 200 reports.