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Sequential development of neuropathological changes in Parkinson’s disease, starting from a healthy brain and leading to the appearance of the disease. The accumulation of dopamine and the creation of Lewy bodies cause deterioration of dopaminergic neurons in the substantia nigra. This disrupts both motor and nonmotor pathways, such as the nigrostriatal, mesocortical, mesolimbic, and tubero-infundibular pathways, ultimately leading to the appearance of symptoms.
