Fig. 3.

Increasing MeCP2 levels reverses abnormal phenotypes in Tcf4^+/− mice.

(A-B) Tcf4^+/− mice (20–26 weeks of age) exhibit hyperlocomotive activity in an open field chamber, (C) enhanced vertical activity in an open field chamber, and (D) increased time spent in the open arms of an elevated zero maze (green versus black bars). All of these abnormal responses in Tcf4^+/− compared animals are normalized to Tcf4^+/+ levels in the presence of the MeCP2 transgene. n ​= ​8–16 mice per genotype. Statistical analysis was performed using 1-way ANOVA with Tukey's post-hoc test. ∗p ​< ​0.05, ∗∗p ​< ​0.01, ∗∗∗p ​< ​0.001, ∗∗∗∗p ​< ​0.0001, ns (not significant) for panels B, C, and D and 2-way ANOVA was used in time course locomotion data (A). Open circle/black bars ​= ​Tcf4^+/+, blue squares/bars ​= ​MECP2^Tg1/o, green triangles/bars ​= ​Tcf4^+/−, pink diamonds/bars ​= ​MECP2^Tg1/o; Tcf4^+/−.