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. 2024 Nov 20;46(2):2431150. doi: 10.1080/0886022X.2024.2431150

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© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 1. — The protein expressions of TRPC6, LONP1 and p-ERK1/2 in the kidney tissues of MCD patients.

(A-D) The expressions of TRPC6, p-ERK1/2, and LONP1 in the kidney tissues of MCD patients were detected by immunohistochemistry (magnification: ×400, scale bar = 100 µm). (E-H) The protein expressions of TRPC6, p-ERK1/2, ERK1/2 and LONP1 in the kidney tissues were measured by Western blot. GAPDH was used as a loading control. (I) The correlation between TRPC6 and p-ERK1/2 (r = -0.998, p < 0.001). (J) The correlation between TRPC6 and LONP1 (r = -0.994, p < 0.001). (K) The correlation between LONP1 and p-ERK1/2 (r = 0.992, p < 0.001). The data are presented as the mean ± standard deviation of three independent experiments; **p < 0.01, ***p < 0.001 vs. Control. Abbreviation: TRPC6, transient receptor potential cation channel subfamily C member 6; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; LONP1, Lon peptidase 1; ERK, extracellular signal-regulated kinase; p-ERK, phosphorylated ERK.