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. 2024 Nov 16;6(6):fcae408. doi: 10.1093/braincomms/fcae408

Figure 1.

Figure 1

Brain images of four individuals with a loss of PLAT function. (A–C). MRI images from Individual 1.1 at 7 years of age. (A) Sagittal constructive interference in steady state (CISS) image. The arrow points to CSF flow artefacts (enlarged in the inset) suggesting the presence of a membrane (not visualized because of these artefacts) at the outlets of the fourth ventricle. (B) Axial T2 image showing significant enlargement of both lateral ventricles with frontal predominance and absent septum pellucidum and subependymal heterotopia (arrow). (C) Axial T2 image showing dilated 4th ventricle with turbulent cerebrospinal fluid. (D–F) Images from foetus 1.2 at 23 3/7 weeks of gestation. (D) Sagittal T2 image showing dilated fourth ventricle. (E). Axial T2 image showing dilatation of both lateral ventricles. (F). Oblique coronal image showing hypoplastic cerebellum (arrow) and dilated fourth ventricle. (G–I). MRI images from Individual 2.2 at 19 months of age. (G). Sagittal 3D Fiesta showing a membrane at the central outlet of the fourth ventricle (arrow). (H). Axial T2 reformat showing absent septum pellucidum, subependymal heterotopia and ventricular shunt with residual hydrocephalus. (I). Enlargement of fourth ventricle with dysplastic cerebellar hemispheres. (J–L). Axial CT-scan images from Individual 3.1 at 1 year of age, showing significant enlargement of both lateral ventricles (J, K) and the fourth ventricle (L).