Table 2.
Radiological features of AACNLI patients with good and poor outcome (training set + internal test set)
| Features | Good Outcome (n = 132) | Poor Outcome (n = 115) | P-value |
|---|---|---|---|
| Interval from onset to MRI (h) | 35 (22, 50.5) | 36 (21, 53) | 0.975 |
| CBS | 10 (8, 10) | 8 (6, 10) | <0.001 |
| HT | 13 (9.8%) | 21 (18.3%) | 0.056 |
| DWI-ASPECTS | 7 (6, 8) | 5 (3, 7) | <0.001 |
| Contralateral brain ADC (×10−6 mm2/s) | 777 (50) | 784 (53) | 0.254 |
| DWI-FLAIR mismatch | 4 (3.0%) | 7 (6.1%) | 0.245 |
| DWI-FVH mismatch | 92 (69.7%) | 69 (60.0%) | 0.111 |
| FVH score | 2 (1, 4) | 3 (1, 4) | 0.357 |
| Fazekas score | 2 (2, 3) | 3 (2, 4) | 0.092 |
| Mask DWI | |||
| V1 (ml) | 10.29 (4.93, 23.57) | 46.99 (15.05, 149.04) | <0.001 |
| V1max (ml) | 8.84 (3.80, 19.06) | 41.16 (13.08, 149.04) | <0.001 |
| P1 | 0.87 (0.68, 0.99) | 0.99 (0.93, 1.00) | <0.001 |
| N1 | 6 (2, 11) | 4 (2, 10) | 0.095 |
| ADC1mean (×10−6 mm2/s) | 599 (537, 666) | 565 (507, 640) | 0.063 |
| ADC1SD (×10−6 mm2/s) | 177 (145, 221) | 193 (162, 252) | 0.013 |
| ADC1CV | 0.31 (0.25, 0.35) | 0.34 (0.29, 0.41) | <0.001 |
| Grad1mean | 8576 (6665, 11047) | 8665 (7161, 10839) | 0.659 |
| Grad1SD | 8112 (5486, 11109) | 9144 (7100, 11424) | 0.070 |
| Grad1CV | 0.92 (0.79, 1.06) | 1.04 (0.89, 1.16) | <0.001 |
| rADC1 | 0.75 (0.68, 0.87) | 0.72 (0.64, 0.83) | 0.018 |
| Mask ADC620 | |||
| V2 (ml) | 5.81 (3.31, 14.58) | 34.68 (10.16, 115.82) | <0.001 |
| V2max (ml) | 4.91 (2.25, 13.42) | 34.60 (7.08, 114.78) | <0.001 |
| P2 | 0.90 (0.64, 0.98) | 0.99 (0.88, 1.00) | <0.001 |
| N2 | 7 (3, 12) | 9 (3, 16) | 0.108 |
| ADC2mean (×10−6 mm2/s) | 496 (40) | 477 (40) | <0.001 |
| ADC2SD (×10−6 mm2/s) | 75 (61, 95) | 89 (74, 100) | 0.001 |
| ADC2CV | 0.15 (0.12, 0.20) | 0.19 (0.15, 0.22) | 0.001 |
| Grad2mean | 7336 (6017, 9726) | 7856 (6648, 9301) | 0.237 |
| Grad2SD | 6741 (4574, 9561) | 8153 (6440, 10203) | 0.003 |
| Grad2CV | 0.88 (0.74, 1.04) | 1.06 (0.85, 1.15) | <0.001 |
| rADC2 | 0.64 (0.06) | 0.61 (0.06) | <0.001 |
| Mask ADC | |||
| V3 (ml) | 5.32 (2.87, 13.07) | 31.76 (8.22, 110.61) | <0.001 |
| V3max (ml) | 4.11 (1.79, 11.10) | 30.61 (5.94, 109.46) | <0.001 |
| P3 | 0.88 (0.63, 0.99) | 0.99 (0.86, 1.00) | <0.001 |
| N3 | 8 (4, 14) | 10 (4, 21) | 0.049 |
| ADC3mean (×10−6 mm2/s) | 499 (455, 526) | 469 (446, 508) | 0.003 |
| ADC3SD (×10−6 mm2/s) | 75 (62, 94) | 90 (72, 99) | 0.001 |
| ADC3CV | 0.15 (0.12, 0.21) | 0.19 (0.15, 0.22) | 0.001 |
| Grad3mean | 7336 (5986, 9529) | 7707 (6481, 9069) | 0.448 |
| Grad3SD | 6804 (4644, 9595) | 8117 (6373, 10033) | 0.007 |
| Grad3CV | 0.89 (0.74, 1.05) | 1.07 (0.89, 1.19) | <0.001 |
| rADC3 | 0.63 (0.07) | 0.60 (0.06) | <0.001 |
All categorical variables are expressed as n (%) and continuous variables as median (IQR) or mean (SD).
ADC, apparent diffusion coefficient; ASPECTS, Alberta Stroke Program Early CT Score; CBS, clot burden score; CV, coefficient of variation; DWI, diffusion-weighted imaging; FLAIR, fluid-attenuated inversion recovery; FVH, FLAIR vascular hyperintensity; Grad, gradient; HT, haemorrhage transformation; IQR, interquartile range; N, number of the lesions; P, proportion (Vmax/V); SD, standard deviation; V, total volume of the lesions; Vmax, volume of the largest lesion.