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. 2024 Nov 21;24:839. doi: 10.1186/s12888-024-06281-2

Table 2.

Multivariable logistic regression showing factors associated with non-remission and non-response

Whole sample (n = 4153)
Non-remissiona (n = 784) Non-responseb (n = 956)
aOR 95% CI p aOR 95% CI p
Personal background factors
 Male sex (Ref) (Ref)
 Female sex 1.09 0.87–1.35 0.47 1.15 0.93–1.41 0.19
 Age 1.00 0.99–1.02 0.67 1.01 0.99–1.02 0.42
 Years of education 1.01 0.99–1.03 0.32 1.01 0.99–1.03 0.19
 Not receiving social security assistance (Ref) (Ref)
 Receiving social security assistance 1.35 1.11–1.65 0.002 1.19 0.99–1.43 0.061
 Living with others (Ref) (Ref)
 Living alone 0.85 0.71–1.01 0.070 0.97 0.82–1.14 0.70
Prior stress exposure
 No history of abuse (Ref) (Ref)
 Has history of abuse 1.49 1.02–2.18 0.037 1.32 0.88–1.97 0.19
Psychiatric and physical illness history
 No diagnosis of depression/anxiety (Ref) (Ref)
 Has diagnosis of depression/anxiety 0.87 0.69–1.08 0.21 0.78 0.62–0.98 0.035
 No multimorbidity (< 4 chronic diseases) (Ref) (Ref)
 Has multimorbidity (≥ 4 chronic diseases) 0.85 0.58–1.23 0.39 0.70 0.50–0.98 0.037
 No chronic pain (Ref) (Ref)
 Has chronic pain 0.59 0.48–0.72 < 0.001 0.76 0.64–0.91 0.002
Need for informal care
 No informal care required for mental health reasons (Ref) (Ref)
 Informal care required for mental health reasons 1.86 1.49–2.33 < 0.001 1.48 1.19–1.85 < 0.001
Cognition
 Cognitive capacity (MoCA 5-min) 0.95 0.93–0.97 < 0.001 0.94 0.92–0.96 < 0.001
Current suicidal ideation
 No suicidal ideation (Ref) (Ref)
 Has suicidal ideation 1.32 1.08–1.62 0.007 1.04 0.84–1.29 0.72
Mental health symptoms
 No-to-mild depressive symptoms (PHQ-9 < 10) (Ref) (Ref)
 Moderate-to-severe depressive symptoms (PHQ-9 ≥ 10) 1.41 1.18–1.69 < 0.001 0.28 0.23–0.34 < 0.001
 No-to-mild anxiety symptoms (GAD-7 < 10) (Ref) (Ref)
 Moderate-to-severe anxiety symptoms (GAD-7 ≥ 10) 2.08 1.72–2.51 < 0.001 1.28 1.05–1.57 0.015
 Low loneliness (UCLA3 < 7) (Ref) (Ref)
 High loneliness (UCLA3 ≥ 7) 2.00 1.66–2.42 < 0.001 1.67 1.38–2.01 < 0.001

Statistics significant at the p < 0.05 level are boldfaced. GAD-7 7-item Generalized Anxiety Disorder scale, MoCA 5-min Montreal Cognitive Assessment 5-min, PHQ-9 9-item Patient Health Questionnaire, UCLA3 UCLA 3-item Loneliness Scale

a Non-remission is defined PHQ-9 ≥ 5 post-intervention, which is indicative of failure to achieve clinical remission

b Non-response is defined < 50% reduction in PHQ-9 post-intervention, which is indicative of failure to achieve clinical response