TABLE 2.

MR identifies significant effect of IBD susceptibility variants on CDI^a,b

Exposure	Method	N	Beta	P value	OR
Outcome: CDI
IBD	MR Egger	105	0.145	0.027	1.156 (1.018–1.312)
IBD	Inverse variance weighted	105	0.091	0.001	1.096 (1.040–1.154)
CD	MR Egger	97	0.082	0.188	1.085 (0.962–1.225)
CD	Inverse variance weighted	97	0.060	0.008	1.061 (1.016–1.109)
UC	MR Egger	62	0.197	0.010	1.218 (1.053–1.410)
UC	Inverse variance weighted	62	0.103	0.0003	1.109 (1.049–1.173)
Outcome: IBD
CDI	MR Egger	5	0.178	0.669	1.195 (0.571–2.498)
CDI	Inverse variance weighted	5	0.054	0.424	1.055 (0.925–1.203)

^a Sensitivity analyses with disease subtypes highlight effect driven by UC susceptibility variants, rather than CD. N denotes the number of SNPs for the exposure variable.

^b CDI, Clostridioides difficile infection; IBD, inflammatory bowel disease; MR, Mendelian randomization; UC, ulcerative colitis.