Fig 2.

Injection site reactions measured on day 1 post-injection of high-dose RRwP and high-dose wP vaccines. Four baboons each were vaccinated with high-dose wP or high-dose RRwP vaccines prepared as described in Materials and Methods. On day 1 post-vaccination, the injection sites of all eight animals were evaluated for redness, induration, swelling, and temperature by a veterinarian blinded to treatment groups. Relative clinical scores were assigned by the veterinarian. The non-injected arm served as a negative control for each animal. The injection site temperature is reported as a ratio of the injected arm injection site temperature relative to the control arm mock injection site temperature. In addition to the evaluation of the injection site, the core body temperature was measured and reported as a ratio relative to the temperature of each animal measured on day 0 just before vaccination. Comparisons between groups were made using the nonparametric two-tailed unpaired Mann–Whitney U test. Data are presented as mean ± standard deviation (SD). Statistical difference in site-reactions between high-dose vaccines was observed for redness.