Table 2.

Representative natural products coordinated with Fe^2+/3+

NO	Natural Products	Metal ions	Preparation	TME Response	Size	Treatment	Bioimaging	Reference
1	Dopamine, DA	Fe3+	Mixing	pH, GSH	204 nm	CT/CDT/PTT	——	[39]
2	Tannic acid, TA	Fe3+	–	pH	95.6 nm	CT/PTT	MRI	[33]
3	Tannic acid, TA	Fe3+	Stirring and Ultrasound	pH, ATP	121.17 nm	CT/PTT	PAI/MRI/PTI	[32]
4	Tannic acid, TA	Fe3+	–	ATP	257 nm	CDT/CT	PAI/FI	[35]
5	Tannic acid, TA	Fe3+	–	NIR	> 200 nm	PTT	MRI/PTI	[31]
6	Ellagic acid, EA	Fe3+	Magnetic stirring	TME	25 nm	PTT	PAI/MRI	[38]
7	Porphyrin	Fe3+	Stirring	pH, GSH	145 ± 20 nm	CDT/PDT	FI/MRI	[41]
8	Hematoporphyrin monomethyl ether, HMME	Fe3+	Magnetic stirring	pH, US	~ 70 nm	CT	MRI	[42]
9	Gallic acid, GA	Fe3+	–	pH	110 nm	CT/PTT	MRI	[36]
10	Artemisinin, ART	Fe3+	Magnetic stirring	pH, GSH	80 ± 8.9 nm	CT/CDT	MRI	[44]
11	Tartaric acid, TA	Fe3+	Magnetic stirring	pH	~ 125 nm	CDT/PTT	PTI	[60]
12	Tannic acid, TA	Fe3+	–	–	260.13 ± 1.86 nm	PTT/ICD	PTI	[34]
13	Tannic acid, TA	Fe3+	–	pH, ATP	< 500 nm	CT/PTT	–	[61]
14	Tannic acid, TA	Fe2+	–	pH	–	CT	–	[45]
15	Doxorubicin, DOX	Fe3+	–	pH	–	CT	–	[15]
16	Gallic acid, GA	Fe3+	–	pH	200 nm	CT/CDT	MRI/PTI	[37]
17	Baicalein	Fe2+	Stirring	——	160 nm	CDT/PTT	–	[62]
18	Epigallocatechin-3-gallate, EGCG	Fe3+	Magnetic stirring	pH	~ 100 nm	CT/CDT	FI/MRI	[46]
19	Gallic acid, GA	Fe3+	——	pH	200 nm	CT/CDT	–	[63]
20	Dopamine, DA	Fe3+	Magnetic stirring	pH	60 nm	PTT	PAI/PTI	[40]
21	Pemetrexed, PEM; pseudolaric acid B, PAB	Fe3+	Coordination-driven co-assembly	pH	100 nm	CT	MRI/FLI	[43]
22	Shikonin	Fe3+	Magnetic stirring	GSH	48.2 ± 5.4 nm	CT/CDT	MRI	[47]
23	Quercetin, QU; methotrexate, MTX	Fe3+	Magnetic stirring	pH	181 ± 2 nm	ICD/CT	FI	[56]
24	Gallic acid, GA	Fe2+	–	pH	210.1 nm	CT/CDT	FI	[64]
25	Hematoxylin, HMT	Fe3+	In vivo self-assembly	–	–	PTT/ICD	PTI	[65]
26	SiRNA	Fe2+	Quick ultrasonic	pH	180 nm	CT/CDT	MRI	[59]
27	Polyaminopyrrole, Py-NH2	Fe3+	Magnetic stirring	TME	54.3 nm	PTT	PAI/MRI	[66]
28	GAPDH SiRNA	Fe2+	Magnetic stirring	–	–	CDT	FI	[67]
29	Tannic acid, TA	Fe3+	Magnetic stirring	pH	45.0 nm	CT/CDT/IT	MRI	[68]
30	Benzoic acid, TCPP	Fe3+	Stirring	–	245.2 ± 11.2, 58.1 ± 4.8 nm	PDT/CDT	——	[69]
31	Green tea polyphenols, GTP	Fe3+	Ultrasonic	pH	274 nm	CT/PTT/IT	——	[49]
32	Croconaine	Fe3+	——	GSH/pH	91.3 ± 10.4 nm	PTT/CDT	PAI/PTI	[55]
33	Doxorubicin, DOX	Fe2+	Magnetic stirring	pH/H2O2	∼110 nm	CT/CDT/ICD	FI	[70]
34	Cinnamaldehyde, CA; DOX	Fe3+	Magnetic stirring	pH/H2O2	~ 100 nm	CT/CDT	–	[57]
35	Doxorubicin, DOX	Fe3+	Magnetic stirring	pH	77.3 ± 5.3 nm	CT	–	[71]
36	Hyaluronic acid, HA	Fe3+	Magnetic stirring	pH	225 nm	PTT	PAI	[72]
37	Artemisinin, ART; TiO2	Fe3+	Magnetic stirring	——	170 ± 20 nm	SDT/CDT	–	[73]
38	Amino acids	Fe3+	——	TME	100–140 nm		–	[74]
39	Gallic acid, GA; 5-fluorouracil	Fe3+	Magnetic stirring	DFO	139 nm	CT/PTT	PAI/PTI	[50]
40	Epigallocatechin gallate, EGCG	Fe3+	Magnetic stirring	pH	123.7 nm	PTT/CDT/CT	FI	[75]
41	Epigallocatechin gallate, EGCG	Fe3+	Magnetic stirring	TME	240 nm	PTT/PDT/	FI/PTI	[52]
42	Tannic acid, TA	Fe3+	Magnetic stirring; Ultrasonic	pH	200 nm	CDT/ICD	FI	[76]
43	Polydopamine, PDA	Fe3+	Magnetic stirring	hyperthermia/pH	129.1 ± 6.6 nm	CDT/PTT	FI/PTI	[77]
44	DNAzyme	Fe3+	Vortex	pH	200 nm	CDT/CT	FI	[78]
45	Gossypol	Fe3+	Solvothermal Decomposition	pH/laser	~ 60 nm	CT/PTT	FI/MRI	[58]
46	Lenvatinib, Adriamycin	Fe3+	–	pH	121 ± 3.74 nm	CT/ICD	FI	[79]
47	Apigenin	Fe3+	Magnetic stirring	pH/GSH	264.7 ± 56.2 nm		FI/MRI	[80]