Table 4.

Representative natural products coordinated with Mn^2+/3+

NO	Natural products	Metal ions	Preparation	TME Response	Size	Treatment	Bioimaging	Reference
1	Tannic acid, TA	Mn2+	Stirring	pH, GSH	151 ± 24 nm	GT/CT	FI	[141]
2	Tannic acid, TA	Mn2+	High temperature heating	pH, GSH	~ 230 nm	CDT/GT/CT	FI	[142]
3	Methotrexate, MTX	Mn2+	Sonication	pH	93.3 ± 10.3 nm	CT	MRI	[143]
4	Polydopamine, PDA	Mn2+	Magnetic stirring	–	105 nm	CDT/PTT	MRI/PTI /FI	[147]
5	Hematoporphyrin monomethyl ether, HMME	Mn3+	Mild sonication	GSH	~ 100 nm	CT/CDT/PDT	MRI	[144]
6	Doxorubicin, DOX; chlorin e6, Ce6	Mn2+	Sonication	pH	125 ± 6.1 nm	CT/PDT	MRI	[136]
7	Carrying DNA	Mn2+	–	pH	~ 100 nm	CDT	–	[148]
8	Cyclic dinucleotide, CDN	Mn2+	–	pH	118 ± 41 nm	ICD	–	[138]
9	Indocyanine green, ICG	Mn2+	Magnetic stirring	pH	144.87 ± 2.91 nm	CT/CDT/PTT	FI/MRI	[145]
10	Beomycin, BLM	Mn2+	In Vivo self-assembly	GSH	~ 300 nm	CT	MRI	[146]
11	Resiquimod R848	Mn2+	Stirring	pH	~ 100 nm	PTT/ICD/CDT	FI/PAI	[140]
12	Gallic acid, GA	Mn2+	Magnetic stirring	pH	164.2 nm	PTT	PTI	[137]
13	2-methylimidazole, 2-MI	Mn2+	Magnetic stirring	pH	~ 130 nm	ICD	FI	[135]
14	Banoxantrone; AQ4N	Mn2+	Magnetic stirring	pH	~ 100 nm	CT	PAI	[134]