Table 5.

Representative natural products coordinated with Zn²⁺

NO	Natural products	Metal ions	Preparation	TME Response	Size	Treatment	Bioimaging	Reference
1	Fluorouracil	Zn2+	Ultrasound	pH/ATP	100 nm	ICD	FI	[150]
2	IR780-1, 2-methyl-imidazole, siRNA	Zn2+	Stirring	NIR	150–200 nm	PTT/GT	PTI/PAI/FI	[156]
3	RNA	Zn2+	Stirring	–	60–120 nm	CT	FI	[151]
4	L-cystine	Zn2+	Stirring	GSH	189.1 ± 3.8 nm	CT	–	[152]
5	Dipicolylamine-Arg-Gly-Asp, Au, ICG	Zn2+	In Vivo assembled	NIR	100 nm	PTT	FI/PAI/MRI	[153]