Fig. 3. P. aeruginosa bioburden in the acute pneumonia model 24 h after challenge. (a) Bioburden in the lungs and stomach of mice challenged with PBS, low, medium or high bacterial doses. (b) Relative weight lost or gained by mice relative to that before the procedure. (c) Severity score reached after the challenge. In all graphs, results are represented with the mean±sem (n=6–7, except for two groups which were n=2 and n=4, as part of the initial dose-finding pilot study), with each point representing one mouse. Statistical differences between organs (a) or with the control group (b, c) were determined using one-way ANOVA (P value < 0.05) (*P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001).
