Table 2. Predicted cellular localization of principal class D β-lactamases.
In the organism column are specified the most reported organism carrying the lactamase gene or the order they belong to. The three OXA proteins selected in this study are highlighted in red (OXA-23, 24/40 and 48, the representative members of each of these families). Supplementary Table 2 describes all OXA-subfamilies.
| Class D β-lactamase | Number of enzymes | Organism(s) | Predicted cell localization |
|---|---|---|---|
| OXA-1-like | 12 | Pseudomonadales, Shewanellaceae, Pasteurellales, Enterobacterales | soluble |
| OXA-2-like | 31 | Pseudomonadales, Burkholderiales, Shewanellaceae, Enterobacterales, Vibrionales, Pasteurellales | soluble |
| OXA-10-like | 60 | Burkholderiales, Pseudomonadales, Shewanellaceae, Enterobacterales | soluble |
| OXA-22-like | 7 | Ralstonia spp. | soluble |
| OXA-23-like | 49 | Acinetobacter spp. ˟ | lipidated |
| OXA-24/40-like | 24 | Acinetobacter spp. | lipidated |
| OXA-48-like | 66 | Enterobacterales, Shewanellaceae | soluble |
| OXA-50-like | 60 | Pseudomonas spp. | soluble |
| OXA-51-like | 382 | Acinetobacter spp. | lipidated |
| OXA-58-like | 8 | Acinetobacter spp. | lipidated |
| OXA-60-like | 7 | Ralstonia spp. | soluble |
| OXA-134-like | 34 | Acinetobacter spp. | lipidated |
| OXA-61-like | 49 | Campylobacter spp. | soluble |
| OXA-211-like | 17 | Acinetobacter spp. | lipidated |
| OXA-213-like | 51 | Acinetobacter spp. | lipidated |