Table 4: Temporal lobe meta-analysis DEGs unique to our study.
List of differentially expressed genes in temporal lobe meta-analysis that were unique to our study when compared to 8 other temporal lobe studies included in this systematic review. P-value derived from the Inverse-Variance Weighted Fixed-Effect Model from METAL (n=319).
| Gene symbol | Gene ID | Study direction | Regulation | p-value |
|---|---|---|---|---|
| DCAF12 | ENSG00000198876 | ++ | Upregulated in AD | 3.74E-09 |
| PLPP1 | ENSG00000067113 | ++ | Upregulated in AD | 8.83E-08 |
| IGF1R | ENSG00000140443 | ++ | Upregulated in AD | 1.32E-07 |
| WDR1 | ENSG00000071127 | ++ | Upregulated in AD | 1.73E-07 |
| HADH | ENSG00000138796 | ++ | Upregulated in AD | 3.83E-07 |
| MED1 | ENSG00000125686 | ++ | Upregulated in AD | 6.04E-07 |
| SPECC1L | ENSG00000100014 | ++ | Upregulated in AD | 7.93E-07 |
| RSU1 | ENSG00000148484 | ++ | Upregulated in AD | 7.98E-07 |
| DCAF1 | ENSG00000145041 | ++ | Upregulated in AD | 9.89E-07 |
| ZMPSTE24 | ENSG00000084073 | ++ | Upregulated in AD | 1.11E-06 |
| UBAP1 | ENSG00000165006 | ++ | Upregulated in AD | 1.11E-06 |
| DDX58 | ENSG00000107201 | ++ | Upregulated in AD | 1.45E-06 |
| SIK2 | ENSG00000170145 | ++ | Upregulated in AD | 1.81E-06 |
| FANCE | ENSG00000112039 | ++ | Upregulated in AD | 2.48E-06 |
| MCMBP | ENSG00000197771 | ++ | Upregulated in AD | 3.01E-06 |
| CBX5 | ENSG00000094916 | ++ | Upregulated in AD | 3.03E-06 |
| LRRC39 | ENSG00000122477 | −− | Downregulated in AD | 5.18E-09 |
| CCDC102B | ENSG00000150636 | −− | Downregulated in AD | 1.82E-08 |
| DMAC1 | ENSG00000137038 | −− | Downregulated in AD | 6.65E-08 |
| MRPS25 | ENSG00000131368 | −− | Downregulated in AD | 7.67E-08 |
| TAF1D | ENSG00000166012 | −− | Downregulated in AD | 9.26E-08 |
| CHCHD7 | ENSG00000170791 | −− | Downregulated in AD | 1.07E-07 |
| ZNF23 | ENSG00000167377 | −− | Downregulated in AD | 1.77E-07 |
| PDCD6 | ENSG00000249915 | −− | Downregulated in AD | 2.02E-07 |
| ITPA | ENSG00000125877 | −− | Downregulated in AD | 2.02E-07 |
| LETMD1 | ENSG00000050426 | −− | Downregulated in AD | 4.22E-07 |
| AMY2B | ENSG00000240038 | −− | Downregulated in AD | 4.52E-07 |
| SMIM10L1 | ENSG00000256537 | −− | Downregulated in AD | 6.69E-07 |
| PARL | ENSG00000175193 | −− | Downregulated in AD | 8.46E-07 |
| ELP2 | ENSG00000134759 | −− | Downregulated in AD | 8.83E-07 |
| AZIN2 | ENSG00000142920 | −− | Downregulated in AD | 8.90E-07 |
| CNPY2 | ENSG00000257727 | −− | Downregulated in AD | 1.01E-06 |
| MDP1 | ENSG00000213920 | −− | Downregulated in AD | 1.02E-06 |
| ANAPC4 | ENSG00000053900 | −− | Downregulated in AD | 1.19E-06 |
| SFPQ | ENSG00000116560 | −− | Downregulated in AD | 1.34E-06 |
| TUBGCP2 | ENSG00000130640 | −− | Downregulated in AD | 1.43E-06 |
| RBM45 | ENSG00000155636 | −− | Downregulated in AD | 1.61E-06 |
| CDK5RAP1 | ENSG00000101391 | −− | Downregulated in AD | 1.84E-06 |
| SNRNP40 | ENSG00000060688 | −− | Downregulated in AD | 1.85E-06 |
| RNF34 | ENSG00000170633 | −− | Downregulated in AD | 2.63E-06 |
| GTF2H5 | ENSG00000272047 | −− | Downregulated in AD | 2.77E-06 |