Table 5: Frontal lobe meta-analysis DEGs unique to our study.
List of differentially expressed genes in frontal lobe meta-analysis that were unique to our study when compared to 3 other frontal lobe studies included in this systematic review. P-value derived from the Inverse-Variance Weighted Fixed-Effect Model from METAL (n=599).
| Gene symbol | Gene ID | Direction | Regulation | p-value |
|---|---|---|---|---|
| MVB12B | ENSG00000196814 | ++ | Upregulated in AD | 6.58E-09 |
| TMCC2 | ENSG00000133069 | ++ | Upregulated in AD | 8.27E-09 |
| SAMD4A | ENSG00000020577 | ++ | Upregulated in AD | 1.24E-08 |
| HSPB2 | ENSG00000170276 | ++ | Upregulated in AD | 1.63E-08 |
| TCEA3 | ENSG00000204219 | ++ | Upregulated in AD | 3.53E-08 |
| HOMER3 | ENSG00000051128 | ++ | Upregulated in AD | 3.61E-08 |
| VAT1 | ENSG00000108828 | ++ | Upregulated in AD | 4.55E-08 |
| AC106886.5 | ENSG00000282034 | ++ | Upregulated in AD | 4.62E-08 |
| ECE1 | ENSG00000117298 | ++ | Upregulated in AD | 1.41E-07 |
| HMBOX1 | ENSG00000147421 | ++ | Upregulated in AD | 1.60E-07 |
| ANKRD40 | ENSG00000154945 | ++ | Upregulated in AD | 1.66E-07 |
| MICALL1 | ENSG00000100139 | ++ | Upregulated in AD | 2.54E-07 |
| MID1IP1 | ENSG00000165175 | ++ | Upregulated in AD | 2.68E-07 |
| FGD5 | ENSG00000154783 | ++ | Upregulated in AD | 2.98E-07 |
| ITPRIP | ENSG00000148841 | ++ | Upregulated in AD | 3.47E-07 |
| ARHGEF37 | ENSG00000183111 | ++ | Upregulated in AD | 3.75E-07 |
| CARHSP1 | ENSG00000153048 | ++ | Upregulated in AD | 3.84E-07 |
| PLEKHM2 | ENSG00000116786 | ++ | Upregulated in AD | 3.95E-07 |
| LLGL1 | ENSG00000131899 | ++ | Upregulated in AD | 4.02E-07 |
| KIF1C | ENSG00000129250 | ++ | Upregulated in AD | 5.35E-07 |
| CUEDC1 | ENSG00000180891 | ++ | Upregulated in AD | 5.48E-07 |
| ARAP1 | ENSG00000186635 | ++ | Upregulated in AD | 6.09E-07 |
| NXN | ENSG00000167693 | ++ | Upregulated in AD | 6.98E-07 |
| ARHGAP17 | ENSG00000140750 | ++ | Upregulated in AD | 7.98E-07 |
| TNS1 | ENSG00000079308 | ++ | Upregulated in AD | 9.94E-07 |
| EFHD1 | ENSG00000115468 | ++ | Upregulated in AD | 1.45E-06 |
| DLL4 | ENSG00000128917 | ++ | Upregulated in AD | 1.49E-06 |
| APOD | ENSG00000189058 | ++ | Upregulated in AD | 1.58E-06 |
| ESAM | ENSG00000149564 | ++ | Upregulated in AD | 2.05E-06 |
| MFGE8 | ENSG00000140545 | ++ | Upregulated in AD | 2.64E-06 |
| SLCO3A1 | ENSG00000176463 | ++ | Upregulated in AD | 2.85E-06 |
| NDE1 | ENSG00000072864 | ++ | Upregulated in AD | 3.10E-06 |
| LY6K | ENSG00000160886 | −− | Downregulated in AD | 3.26E-07 |
| ST6GAL2 | ENSG00000144057 | −− | Downregulated in AD | 9.91E-07 |
| NOL4 | ENSG00000101746 | −− | Downregulated in AD | 1.01E-06 |
| RNF150 | ENSG00000170153 | −− | Downregulated in AD | 1.23E-06 |
| SCG3 | ENSG00000104112 | −− | Downregulated in AD | 2.14E-06 |
| AGBL4 | ENSG00000186094 | −− | Downregulated in AD | 2.27E-06 |
| TNFRSF11A | ENSG00000141655 | −− | Downregulated in AD | 2.54E-06 |