Figure 4. CGRP-dependent potentiation and input strength is not lateralized, and response to CGRP is not due to experimental variables.
All data from female CeLC neurons. Potentiation is indistinguishable in neurons in the left or right CeLC (A). Two measures of PBCGRP glutamatergic input strength, oEPSC baseline amplitudes (B) and paired pulse ratios at baseline (C) also show no lateralization. Potential experimental sources of heterogeneity are not correlated with potentiation – animal age (D); virus incubation time (E) do not differ between responder neurons (>20% potentiation) and non-responder neurons. Similarly, access resistance (F), baseline current (G), membrane resistance (H) or cell capacitance (I) show no difference between responders and non-responders.