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. 2024 Nov 17;13(1):2429846. doi: 10.1080/2162402X.2024.2429846

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 5. — The production of new myeloid cells, in the bone marrow, is dependent on TLR7 and partially dependent on IFN-I signaling. (a) Flow cytometry analysis of bone marrow progenitors from representative B6, TLR7 KO and IFNAR KO mice at 24h post-PapMV-injection (left panels) and littermate mice injected with TRIS (right panels). Number (left panel) and percentage (right panel) of (b) CD48+ CD150- and (c) CD48- CD150+ cells in BM at 24 hours post-PapMV-injection. (d) Number (left panel) and percentage (right panel) of CD48+ CD150- cells in splenocytes at 24 hours post-PapMV-injection. (e) Percentage of lin- cKit+ blood cells at 24 hours post-PapMV-injection. Values are means ± SEM and are compiled from three independent experiments. Blood results are from pooled mice (2 animals per data) to increase cell numbers. The B6 data are compiled from all the IFNAR KO and TLR7 KO experiments.