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. 2024 Nov 21;19(11):e0311379. doi: 10.1371/journal.pone.0311379

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Fig 5 — The color keys of log2 (Fold change) were added at top left corners. In the networks, the oval and rectangular shaped nodes represent miRNA and biofunctions, respectively. The edges represent the relationship between two nodes: the solid lines represent their association, and pointed arrowheads denote the activating relationship between the two nodes. Of these, miRNAs that appeared most connected to the neighbors were annotated in the red colored stars for > 90% percentile, and green colored stars for > 75% percentile. (A) Hierarchical cluster of 17 miRNAs that were differentially expressed by the cumulative effects of RD and TSI. These miRNAs are sex-independent markers. (B) Network cluster of the same 17 miRNAs that were differentially expressed by RD*TSI. (C) Hierarchical cluster of 11 miRNAs that were differentially expressed by the cumulative effects of Sex, RD and TSI. (D) Network cluster of the same 11 miRNAs that were differentially expressed by Sex*RD*TSI.