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. 2024 Nov 21;19(11):e0311379. doi: 10.1371/journal.pone.0311379

Table 1. List of bionetworks enriched by a subset of cnvd-miRNA: Bionetworks significantly altered by the cumulative effects of RD and TSI (RD*TSI).

Day 1 Day 2 Day 6
Diseases and Bio Functions 6.0 Gy 6.5 Gy 7.0 Gy 7.5 Gy 8.0 Gy 8.5 Gy 6.0 Gy 6.5 Gy 7.0 Gy 7.5 Gy 8.0 Gy 8.5 Gy 6.0 Gy 6.5 Gy 7.0 Gy 7.5 Gy 8.0 Gy 8.5 Gy
Invasion of tumor cell lines -1.04 -0.47 -1.04 1.5 0.39 -0.33 1.16 0.64 2.65 0.28 -1.04 -0.81 -1.96 -1.16 0.64 2.65 1.79 1.88
Invasion of cells -0.56 -0.83 -1.35 1.77 0.75 -0.7 1.46 0.98 2.83 -0.14 -0.56 -1.14 -1.4 -0.67 0.19 2.04 1.25 2.12
Apoptosis of tumor cell lines 1.43 0.66 0.66 -0.2 1.14 0.18 -0.09 0.66 -1.24 -1.82 1.43 0.66 2.01 1.43 -0.11 -2.01 -1.14 -0.47
Migration of tumor cell lines 0.22 1.21 1.12 1.03 -0.4 -0.76 -1.39 1.03 0.05 1.66 0.22 2.01 0.31 0.58 1.93 0.4 0.4 0.05
Cell proliferation of tumor cell lines -1.12 0.47 -0.81 0.13 0.22 -0.73 0.2 -0.49 1.4 1.14 -1.12 0.5 -1.04 -0.73 0.23 1.71 1.09 1.61
Apoptosis 0.94 0.94 0.2 0.67 1.4 -0.07 0.35 1.5 -0.2 -2.05 0.94 1.5 1.68 1.68 0.76 -0.94 -0.11 0.53
Migration of cells 0.37 1.34 1.25 0.63 -0.82 -1.14 -0.99 0.63 -0.06 2.02 0.37 2.1 0.37 0.63 2.02 0.82 0.31 0.46
Cell viability of tumor cell lines -1.39 -1.39 -1.39 -0.28 -1.94 -0.83 0.28 -0.28 0.83 0.83 -1.39 -0.28 -1.94 -0.83 -0.28 0.83 0.83 -0.28
Cell proliferation of colorectal cancer cell lines -0.18 0.43 -0.93 0.43 -0.58 -0.58 0.18 0.43 1.18 -0.18 -0.18 0.43 0.18 -0.58 0.43 1.18 1.18 1.18
Metastasis -0.19 0.75 0.75 -0.19 -0.19 0.75 0.75 -0.19 0.75 0.19 -0.19 -0.75 -0.19 -1.69 0.75 1.69 1.69 0.75
Cell proliferation of carcinoma cell lines -0.63 -0.63 -0.63 -0.16 -0.16 -1.41 0.63 -0.16 0.63 0.16 -0.63 0.63 -0.63 -0.94 0.63 0.63 0.63 0.63

Bionetworks with a Z score of ≥ 1 and ≤ -1 were considered activated and inhibited networks, respectively. The tables included those bionetworks, which scored ≥ |1| in at least one of all tested conditions.