Table. Baseline Characteristics of the VA Million Veteran Program Cohort.
| Characteristic | Patientsa | ||
|---|---|---|---|
| All (N = 353 153) | No kidney disease progression (n = 336 826)b | Kidney disease progression (n = 16 327)b | |
| Follow-up time, median (IQR), yc | 5.08 (3.15-7.16) | 5.16 (3.21-7.24) | 3.61 (2.15-5.31) |
| Age, median (IQR), y | 66.0 (58.0-72.0) | 66.0 (57.0-72.0) | 67.0 (63.0-73.0) |
| Sex | |||
| Female | 26 553 (7.5) | 25 758 (7.7) | 795 (4.9) |
| Male | 326 599 (92.5) | 311 067 (92.4) | 15 532 (95.1) |
| Comorbidities | |||
| Diabetes | 90 728 (25.7) | 81 304 (24.1) | 9424 (57.7) |
| Obesity (BMI ≥30) | 156 743 (45.0) | 147 646 (44.5) | 9097 (55.8) |
| BMI, median (IQR) | 29.3 (26.0-33.4) | 29.3 (26.0-33.3) | 30.9 (27.1-35.3) |
| eGFR at baseline, median (IQR), mL/min/1.73 m2 | 79.4 (64.8-91.8) | 79.8 (65.5-91.8) | 71.2 (53.0-87.2) |
| HbA1c level, median (IQR), %d | 5.80 (5.50-6.50) | 5.80 (5.50-6.40) | 6.50 (5.80-7.70) |
| Blood pressure, median (IQR), mmHge | |||
| Systolic | 129 (119-138) | 129 (119-138) | 133 (122-143) |
| Diastolic | 76 (69-82) | 76 (70-83) | 74 (67-81) |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; VA, US Department of Veterans Affairs.
a
Data are presented as number (percentage) of patients unless otherwise indicated.
b
Kidney disease progression was defined as an incident decline in eGFR of 40% or end-stage kidney disease.
c
Time to kidney disease progression, death, or the end of the study period.
d
Closest value measured within the prior 2 years.
e
Closest value measured within the past year.