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. 2024 Nov 21;5(12):e70006. doi: 10.1002/mco2.70006

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© 2024 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Signal transducer and activator of transcription 1 (STAT1) overexpression induces cell cycle arrest and inhibits epithelial–mesenchymal transition (EMT). (A) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of differentially expressed proteins (DEPs). (B) Five proteins related to cell cycle were reduced in STAT1‐overexpressing cells. (C) Volcano plot of the distribution of DEPs. CDK6 was significantly downregulated after STAT1 overexpression. (D) Quantitative polymerase chain reaction (qPCR) validation of CDK6, CDK4, and Cyclin D1. (E) Western blotting validation of CDK6, CDK4, and Cyclin D1. (F) STAT1 overexpression induces cell cycle arrest in the G1 phase. (G, H) Western blotting validation of EMT markers in STAT1‐overexpressing cells (G) or knockdown cells (H). Means ± SEM, ****p < 0.0001; Student's t‐test.