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. 2024 Nov 8;15:1478848. doi: 10.3389/fendo.2024.1478848

Table 3.

Impact of anxiety on semen quality based on GLM and regression analysis.

GLM Logistic regression
Normal Mild
anxiety
Moderate to severe anxiety Normal Mild anxiety Moderate to severe anxiety
Na 879 145 29 Na 879 145 29
Semen volume(mL)/Mean (SD) 2.66(1.21) 2.72(1.07) 2.50(1.65) Semen volume<1.5 mL/N(%) 86(9.78) 11(7.59) 6(20.69)
Coefficient (95%CI) ref 0.14
(-0.08, 0.36)
0.07
(-0.38, 0.52)
OR (95%CI) ref 0.56
(0.28, 1.12)
1.25
(0.45, 3.47)
PR(%)/Mean (SD) 42.28(17.75) 39.76(17.68) 39.82(22.36) PR<32%/N(%) 266(30.26) 51(35.17) 12(41.38)
Coefficient (95%CI) ref -1.66
(-4.93, 1.61)
-1.75
(-8.47, 4.98)
OR (95%CI) ref 1.19
(0.80, 1.78)
1.73
(0.78, 3.82)
Total motility
(%)/Mean(SD)
58.67(21.36) 56.17(22.39) 54.85(24.78) Total motility<40%/N(%) 189(21.50) 39(26.90) 10(34.48)
Coefficient(95%CI) ref -1.25
(-5.22, 2.71)
-2.56
(-10.71, 5.59)
OR (95%CI) ref 1.35
(0.87, 2.07)
2.28
(0.99, 5.23)
Concentration(×106/mL)/Mean (SD) 84.65(66.56) 73.98(54.89) 54.22(52.21) Concentration<40×106/mL/N(%) 54(6.14) 8(5.52) 67(6.36)
Coefficient (95%CI) ref -8.29
(-20.14, 3.56)
-25.60
(-49.97, -1.23)*
OR (95%CI) ref 0.90
(0.40, 2.02)
2.96
(0.99, 8.89)
TSC(×106/ejaculate)/Mean(SD) 225.67(205.38) 203.81(193.50) 148.60(212.29) TSC<39×106/ejaculate/N(%) 81(9.22) 16(11.03) 6(20.69)
Coefficient(95%CI) ref -10.42
(-47.42, 26.58)
-46.94
(-123.04, 29.16)
OR (95%CI) ref 1.16
(0.63, 2.13)
2.12
(0.78, 5.76)
Morphology(%)
/Mean (SD)
5.77(3.21) 5.95(3.21) 5.02(2.10) Morphology<4%
/N(%)
307(35.21) 47(33.10) 10(20.69)
Coefficient(95%CI) ref 0.11
(-0.48, 0.71)
-9.24
(-2.18, 0.33)
OR (95%CI) ref 0.93
(0.62, 1.39)
1.12
(0.49, 2.57)
F1/Mean (SD) 0.03(1.47) 0.17(1.49) -0.26(1.77) F1<0.026 (50th percentile)/N(%) 428(49.08) 77(54.23) 15(55.56)
Coefficient (95%CI) ref -0.11
(-0.39, 0.16)
-0.22
(-0.79, 0.36)
OR (95%CI) ref 1.11
(0.76, 1.62)
1.12
(0.50, 2.50)

GLM, generalized regression model; PR, progressive motility; TSC, total sperm count; CI, confidence interval; OR, odds ratio; SD, standard deviation.

a. Data are missing for morphology and F1: Normal (n=7), Mild depression (n=3), Moderate to severe anxiety (n=2).

*P<0.05.